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In diseases characterized by oxidative stress, such as neurodegenerative, inflammatory, cardiovascular disorders and neoplasms, inhibiting ferroptosis via GPX4 can indirectly alleviate associated pain [21, 22]

Other DAMPs which have been observed at elevated levels in the blood or plasma of patients with severe COVID-19 comprise high-mobility group box protein (HMGB)1 (51, 110, 111, 202206), S100 proteins (108, 110, 202, 207209), plasma hyaluronan (210), extracellular (e)ATP (211, 212), the antimicrobial peptide LL-37 (213, 214), histones (e.g (215217), reviewed in (218, 219) and circulating self-DNA, including nDNA (13, 20, 21, 42, 46, 47), mtDNA (13, 18, 21, 42, 43, 48, 49), NET-associated cfDNA (201, 215, 220222), histone-DNA complexes (219), and cfDNA of non-specified subcellular origin (45, 48, 5054)

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Aspartate aminotransferase in synaptic and nonsynaptic mitochondria: differential effect of compounds that influence transient hetero-enzyme complex (metabolon) formation